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Gold-Catalyzed Rearrangement of Alkynyl Donor−Acceptor Cyclopropanes To Construct Highly Functionalized Alkylidenecyclopentenes

Author:Chen Huiyu, Source:Original, Hits:408, UpdateTime:2015-04-24


A gold-catalyzed 1,7-addition−cyclization−elimination cascade sequence performed on a range of
alkynyl-substituted donor−acceptor-type cyclopropanes provides facile entry to highly functionalized exo-alkylidenecyclopentenes under very mild conditions. Isolation of the relevant allyl ether intermediate helped shed light on the reaction’s mechanistic course.