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Visible-Light-Promoted Vinylation of Tetrahydrofuran with Alkynes through Direct C−H Bond Functionalization

Author:Li Jing, Source:Original, Hits:541, UpdateTime:2015-04-24

 

Mild and direct C−H bond functionalizations and vinylations of tetrahydrofuran with alkynes have been accomplished through visible light photocatalysis, yielding a range of vinyl tetrahydrofurans under the synergistic actions of organic dye-type photocatalyst eosin Y, tert-butyl hydroperoxide (t-BuOOH), and a 45 W household lightbulb. A significant kinetic isotope effect (KIE) was recorded, which helps shed light on the mechanistic course.